ben bing pi benzo a pyrene BaP shi huan jing zhong cun zai de yi zhong hua xue zhi ai wu zai ti nei neng you dao ji yin tu bian huo ying xiang xi bao zhou qi diao kong xiang guan ji yin de biao da dao zhi xi bao zhou qi de you xu xing he jing que xing shou dao po huai zao cheng xi bao zhou qi wen luan shen zhi e xing zhuan hua zui zhong fa sheng ai bian ren pei fei cheng xian wei xi bao human embryonic lung fibroblast HELF he ren fei xian ai xi bao xi A549 shi p53 zheng chang biao da xi bao xi ren fei xian ai xi bao xi H1299 shu yu p53 que shi xing xi bao xi ben yan jiu shou xian yong BaP ran du HELF A549 he H1299 xi bao shuo ming BaP neng xian zhu cu jin xi bao de sheng chang he zeng zhi bing qie ju you p53 biao da yi lai xing qi ci dui BaP zuo yong hou xi bao nei p53 ji xia you ji yin he dan bai de biao da jin xing le jian ce shuo ming BaP neng gou tong guo you dao cyclin D1 CDK2 he CDK4 de biao da ying xiang xi bao zhou qi de you xu jin xing yi ai ji yin p53 zai BaP ying xiang xi bao zhou qi diao kong de guo cheng zhong fa hui zhong yao zuo yong p53 zuo wei zhuan lu yin zi ke you dao xia you xiang guan dan bai de biao da cong er da dao diao kong xi bao zhou qi de zuo yong